Version 5.4
Bos taurus Protein: ERCC4
Summary
InnateDB Protein IDBP-689086.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERCC4
Protein Name excision repair cross-complementing rodent repair deficiency, complementation group 4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000043645
InnateDB Gene IDBG-637090 (ERCC4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0001094 TFIID-class transcription factor binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0043566 structure-specific DNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0009411 response to UV
GO:0009650 UV protection
GO:0010834 telomere maintenance via telomere shortening
GO:0032205 negative regulation of telomere maintenance
GO:0033683 nucleotide-excision repair, DNA incision
GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair
Cellular Component
GO:0000109 nucleotide-excision repair complex
GO:0000110 nucleotide-excision repair factor 1 complex
GO:0000781 chromosome, telomeric region
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0005669 transcription factor TFIID complex
Protein Structure and Domains
PDB ID
InterPro IPR006166 ERCC4 domain
IPR006167 DNA repair protein
IPR010994 RuvA domain 2-like
IPR011335 Restriction endonuclease type II-like
PFAM PF02732
PRINTS
PIRSF
SMART SM00891
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BKV9
UniProt Splice Variant
Entrez Gene 516371
UniGene Bt.23646
RefSeq NP_001192289
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057526 DAAA02057527
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca