InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ALDOB

Summary

InnateDB Gene

IDBG-637187.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDOB

Gene Name

fructose-bisphosphate aldolase B

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015358

Encoded Proteins

IDBP-689188

fructose-bisphosphate aldolase B

IDBP-689191

fructose-bisphosphate aldolase B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136872:
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related \'housekeeping\' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5%% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:92773692-92865307

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000065235	ENSBTAP00000054283
ENSBTAT00000020413	ENSBTAP00000020413

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004332	fructose-bisphosphate aldolase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0016829	lyase activity
GO:0042802	identical protein binding
GO:0051117	ATPase binding
GO:0070061	fructose binding

Biological Process

GO:0006000	fructose metabolic process
GO:0006096	glycolytic process
GO:0006116	NADH oxidation
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0032781	positive regulation of ATPase activity
GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly