Version 5.4
Bos taurus Gene: CKAP5
Summary
InnateDB Gene IDBG-637252.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CKAP5
Gene Name cytoskeleton-associated protein 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004448
Encoded Proteins
IDBP-689265
cytoskeleton associated protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175216:
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:77548431-77653734
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005832 ENSBTAP00000005832
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004519 endonuclease activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007051 spindle organization
GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity
GO:0051297 centrosome organization
Cellular Component
GO:0000922 spindle pole
GO:0000930 gamma-tubulin complex
GO:0005813 centrosome
GO:0016020 membrane
GO:0035371 microtubule plus-end
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000175216
View Gene Order
ENSMUSG00000040549
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_245720
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_243078
Loss of Nlp from mitotic centrosomes pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_244487
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_196635
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_202512
Mitotic Anaphase pathway
REACT_253753
Centrosome maturation pathway
KEGG
INOH
PID NCI
aurora_a_pathway
Aurora A signaling
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.11165
RefSeq NM_001191363 XM_005216463
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca