InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ckap5

Summary

InnateDB Gene

IDBG-191253.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ckap5

Gene Name

cytoskeleton associated protein 5

Synonyms

3110043H24Rik; 4930432B04Rik; D730027C18Rik; mKIAA0097; T25636

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040549

Encoded Proteins

IDBP-191255

cytoskeleton associated protein 5

IDBP-191257

cytoskeleton associated protein 5

IDBP-258342

cytoskeleton associated protein 5

IDBP-258344

cytoskeleton associated protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175216:
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:91526762-91620664

Strand

Forward strand

Band

Transcripts

ENSMUST00000099716	ENSMUSP00000097303
ENSMUST00000046769	ENSMUSP00000046263
ENSMUST00000111338	ENSMUSP00000106970
ENSMUST00000111337	ENSMUSP00000106969
ENSMUST00000123253
ENSMUST00000139433
ENSMUST00000133633
ENSMUST00000147809
ENSMUST00000129118

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004519	endonuclease activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0007051	spindle organization
GO:0007067	mitotic nuclear division
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
GO:0050658	RNA transport
GO:0051297	centrosome organization

Cellular Component

GO:0000922	spindle pole
GO:0000930	gamma-tubulin complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0035371	microtubule plus-end
GO:0043234	protein complex