Version 5.4
| Bos taurus Gene: NCF2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-637262.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | NCF2 | ||||||||
| Gene Name | neutrophil cytosol factor 2 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000008004 | ||||||||
| Encoded Proteins |
neutrophil cytosol factor 2
neutrophil cytosol factor 2
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116701:
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 16:66081122-66128113 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Phagosomal maturation (early endosomal stage) pathway
Signaling by VEGF pathway
Signal Transduction pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Class I MHC mediated antigen processing & presentation pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Signaling by VEGF pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Antigen processing-Cross presentation pathway
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Adaptive Immune System pathway
Signal Transduction pathway
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| KEGG |
Leukocyte transendothelial migration pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
Phagosome pathway
Leukocyte transendothelial migration pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
Phagosome pathway
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| INOH | |||||||||
| PID NCI |
RAC1 signaling pathway
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | F1N733 G3N1F9 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 281346 | ||||||||
| UniGene | Bt.143 | ||||||||
| RefSeq | NM_174120 XM_005217265 | ||||||||
| HUGO | HGNC:7661 | ||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02043574 DAAA02043575 DAAA02043576 DAAA02043577 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 281346 | ||||||||