Version 5.4
Bos taurus Gene: UPB1
Summary
InnateDB Gene IDBG-637270.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UPB1
Gene Name beta-ureidopropionase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001325
Encoded Proteins
IDBP-689266
beta-ureidopropionase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100024:
This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:73500519-73527334
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001749 ENSBTAP00000001749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003837 beta-ureidopropionase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological Process
GO:0006807 nitrogen compound metabolic process
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100024
View Gene Order
ENSMUSG00000033427
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1023
Pyrimidine catabolism pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
REACT_236186
Pyrimidine metabolism pathway
REACT_188937
Metabolism pathway
REACT_241108
Pyrimidine catabolism pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00770
Pantothenate and CoA biosynthesis pathway
hsa00410
beta-Alanine metabolism pathway
hsa00983
Drug metabolism pathway
mmu00410
beta-Alanine metabolism pathway
mmu00240
Pyrimidine metabolism pathway
mmu00770
Pantothenate and CoA biosynthesis pathway
mmu00983
Drug metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL A7MBE8
UniProt Splice Variant
Entrez Gene 504557
UniGene Bt.19006
RefSeq NM_001101050
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151517 DAAA02045689 DAAA02045690
GenPept AAI51518
RNA Seq Atlas 504557

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca