InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DDB2

Summary

InnateDB Gene

IDBG-637338.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDB2

Gene Name

DNA damage-binding protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020999

Encoded Proteins

IDBP-689341

DNA damage-binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134574:
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:78289541-78309815

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027965

ENSBTAP00000027965

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006281	DNA repair
GO:0006290	pyrimidine dimer repair
GO:0006974	cellular response to DNA damage stimulus
GO:0009411	response to UV
GO:0016567	protein ubiquitination
GO:0035518	histone H2A monoubiquitination
GO:0051865	protein autoubiquitination
GO:0070914	UV-damage excision repair