Version 5.4
Bos taurus Protein: DDB2
Summary
InnateDB Protein IDBP-689341.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDB2
Protein Name DNA damage-binding protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027965
InnateDB Gene IDBG-637338 (DDB2)
Protein Structure
UniProt Annotation
Function Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4- ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Accumulates at sites of DNA damage following UV irradiation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006290 pyrimidine dimer repair
GO:0006974 cellular response to DNA damage stimulus
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0035518 histone H2A monoubiquitination
GO:0051865 protein autoubiquitination
GO:0070914 UV-damage excision repair
Cellular Component
GO:0005634 nucleus
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VBY8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 519357
UniGene Bt.33161
RefSeq NP_001069256
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120440
GenPept AAI20441

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca