InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RARRES2

Summary

InnateDB Gene

IDBG-637354.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RARRES2

Gene Name

Retinoic acid receptor responder protein 2

Synonyms

TIG2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004215

Encoded Proteins

IDBP-689358

Retinoic acid receptor responder protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21715684

[Homo sapiens] RARRES2 (Chemerin) requires C-terminal proteolytic processing by cysteine cathepsins to selectively attract a specific subset of immunoregulatory APCs, such as immature plasmacytoid dendritic cells. In addition, truncated RARRES2 also displays antibacterial activity against Enterobacteriaceae.

PMID 21715684

[Mus musculus] Rarres2 (Chemerin) requires C-terminal proteolytic processing by cysteine cathepsins to selectively attract a specific subset of immunoregulatory APCs, such as immature plasmacytoid dendritic cells. In addition, truncated Rarres2 also displays antibacterial activity against Enterobacteriaceae. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106538:
This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine, and is truncated on both termini from the proprotein. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:113564407-113567496

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005523

ENSBTAP00000005523

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0001701	in utero embryonic development
GO:0001934	positive regulation of protein phosphorylation
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0010759	positive regulation of macrophage chemotaxis
GO:0030154	cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0048566	embryonic digestive tract development
GO:0050873	brown fat cell differentiation
GO:0050921	positive regulation of chemotaxis
GO:0050994	regulation of lipid catabolic process
GO:2001275	positive regulation of glucose import in response to insulin stimulus

Cellular Component

GO:0005576	extracellular region
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000106538

View Gene Order

ENSMUSG00000009281

View Gene Order

Cross-References

SwissProt

Q29RS5

TrEMBL

B9VR25

UniProt Splice Variant

Entrez Gene

508990

UniGene

RefSeq

NM_001046020

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC114047 FJ594406 HM998290

GenPept

AAI14048 ACM47221 AEK86679

RNA Seq Atlas

508990