InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PHF8

Summary

InnateDB Gene

IDBG-637450.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHF8

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013289

Encoded Proteins

IDBP-689506

PHD finger protein 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172943:
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:96802567-96867773

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017673

ENSBTAP00000017673

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005506	iron ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032452	histone demethylase activity
GO:0032454	histone demethylase activity (H3-K9 specific)
GO:0035064	methylated histone binding
GO:0035575	histone demethylase activity (H4-K20 specific)
GO:0051864	histone demethylase activity (H3-K36 specific)
GO:0071558	histone demethylase activity (H3-K27 specific)

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0033169	histone H3-K9 demethylation
GO:0035574	histone H4-K20 demethylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045943	positive regulation of transcription from RNA polymerase I promoter
GO:0061188	negative regulation of chromatin silencing at rDNA
GO:0070544	histone H3-K36 demethylation
GO:0071557	histone H3-K27 demethylation