Version 5.4
Bos taurus Gene: TNKS2
Summary
InnateDB Gene IDBG-637514.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNKS2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009279
Encoded Proteins
IDBP-689535
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107854:
Gene Information
Type Protein coding
Genomic Location Chromosome 26:13383833-13446978
Strand Forward strand
Band
Transcripts
ENSBTAT00000049112 ENSBTAP00000046048
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006471 protein ADP-ribosylation
GO:0035264 multicellular organism growth
GO:0040014 regulation of multicellular organism growth
GO:0070198 protein localization to chromosome, telomeric region
GO:0070213 protein auto-ADP-ribosylation
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000242 pericentriolar material
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000107854
View Gene Order
ENSMUSG00000024811
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_200766
degradation of AXIN pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_219129
degradation of AXIN pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BMY0
UniProt Splice Variant
Entrez Gene 533901
UniGene Bt.33489
RefSeq
HUGO HGNC:15677
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02058805 DAAA02058806 DAAA02058807
GenPept
RNA Seq Atlas 533901

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca