Version 5.4
Homo sapiens Gene: TNKS2
Summary
InnateDB Gene IDBG-82311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNKS2
Gene Name tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000107854
Encoded Proteins
IDBP-82313
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:91798312-91865276
Strand Forward strand
Band q23.32
Transcripts
ENST00000371627 ENSP00000360689
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006471 protein ADP-ribosylation
GO:0016055 Wnt signaling pathway
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0035264 multicellular organism growth
GO:0040014 regulation of multicellular organism growth
GO:0070198 protein localization to chromosome, telomeric region
GO:0070213 protein auto-ADP-ribosylation
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0000242 pericentriolar material
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024811
View Gene Order
ENSBTAG00000009279
Not yet available
Pathways
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_200766
degradation of AXIN pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9H2K2
TrEMBL
UniProt Splice Variant
Entrez Gene 80351
UniGene Hs.329327 Hs.694877
RefSeq NM_025235 XM_005270185
HUGO HGNC:15677
OMIM 607128
CCDS CCDS7417
HPRD
IMGT
EMBL AF264912 AF305081 AF309033 AF329696 AF342982 AF438201 AK023746 AK314612 AL359707
GenPept AAG25674 AAG44694 AAK13463 AAK25811 AAK82330 AAL40795 BAB14665 BAG37180 CAC78760
RNA Seq Atlas 80351

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca