InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ALAS2

Summary

InnateDB Gene

IDBG-637598.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALAS2

Gene Name

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013178

Encoded Proteins

IDBP-689624

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158578:
The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:97908616-97935775

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017538

ENSBTAP00000017538

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003870	5-aminolevulinate synthase activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0016746	transferase activity, transferring acyl groups
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0001666	response to hypoxia
GO:0006778	porphyrin-containing compound metabolic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0006879	cellular iron ion homeostasis
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0030218	erythrocyte differentiation
GO:0033014	tetrapyrrole biosynthetic process
GO:0042541	hemoglobin biosynthetic process