InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Alas2

Summary

InnateDB Gene

IDBG-178061.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alas2

Gene Name

aminolevulinic acid synthase 2, erythroid

Synonyms

ALAS; Alas-2; ALAS-E; ALASE

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025270

Encoded Proteins

IDBP-178063

aminolevulinic acid synthase 2, erythroid

IDBP-255431

aminolevulinic acid synthase 2, erythroid

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158578:
The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:150547375-150570638

Strand

Forward strand

Band

Transcripts

ENSMUST00000066337	ENSMUSP00000066040
ENSMUST00000112715	ENSMUSP00000108335
ENSMUST00000134670
ENSMUST00000142474

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003870	5-aminolevulinate synthase activity
GO:0005515	protein binding
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0001666	response to hypoxia
GO:0006778	porphyrin-containing compound metabolic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0006879	cellular iron ion homeostasis
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0030218	erythrocyte differentiation
GO:0033014	tetrapyrrole biosynthetic process
GO:0042541	hemoglobin biosynthetic process