Version 5.4
Bos taurus Gene: BT.42818
Summary
InnateDB Gene IDBG-637665.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.42818
Gene Name DNA-directed RNA polymerase III subunit RPC2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004781
Encoded Proteins
IDBP-689711
DNA-directed RNA polymerase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000013503:
This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:70062608-70178439
Strand Forward strand
Band
Transcripts
ENSBTAT00000038043 ENSBTAP00000037862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006383 transcription from RNA polymerase III promoter
GO:0032728 positive regulation of interferon-beta production
GO:0045089 positive regulation of innate immune response
Cellular Component
GO:0005666 DNA-directed RNA polymerase III complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000013503
View Gene Order
ENSMUSG00000034453
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_756
RNA Polymerase III Chain Elongation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_1036
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_347
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_71
Gene Expression pathway
REACT_239142
Innate Immune System pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_233104
RNA Polymerase III Transcription Initiation pathway
REACT_250309
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_230745
Immune System pathway
REACT_251592
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_261233
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_233572
Gene Expression pathway
REACT_221403
RNA Polymerase III Transcription Termination pathway
REACT_237241
RNA Polymerase III Transcription pathway
REACT_240508
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_205207
RNA Polymerase III Chain Elongation pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
mmu00240
Pyrimidine metabolism pathway
mmu03020
RNA polymerase pathway
mmu00230
Purine metabolism pathway
mmu04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BPX6
UniProt Splice Variant
Entrez Gene 540839
UniGene Bt.42818
RefSeq NM_001192789
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02013740 DAAA02013741 DAAA02013742
GenPept
RNA Seq Atlas 540839

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca