Version 5.4
| Bos taurus Gene: SDC1 | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Gene | IDBG-637667.3 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | SDC1 | ||||||||||||||
| Gene Name | Syndecan-1 | ||||||||||||||
| Synonyms | |||||||||||||||
| Species | Bos taurus | ||||||||||||||
| Ensembl Gene | ENSBTAG00000011154 | ||||||||||||||
| Encoded Proteins |
Syndecan-1
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| Protein Structure | |||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
| Entrez Gene | |||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115884:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||
| Type | Protein coding | ||||||||||||||
| Genomic Location | Chromosome 11:78695354-78719306 | ||||||||||||||
| Strand | Forward strand | ||||||||||||||
| Band | |||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME |
Defective EXT2 causes exostoses 2 pathway
Defective CHST6 causes MCDC1 pathway
MPS IIIA - Sanfilippo syndrome A pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
Glycosaminoglycan metabolism pathway
Non-integrin membrane-ECM interactions pathway
Defective CHSY1 causes TPBS pathway
Chondroitin sulfate/dermatan sulfate metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIID - Sanfilippo syndrome D pathway
Diseases associated with glycosaminoglycan metabolism pathway
Chylomicron-mediated lipid transport pathway
Extracellular matrix organization pathway
Retinoid metabolism and transport pathway
MPS IX - Natowicz syndrome pathway
Lipoprotein metabolism pathway
Myoclonic epilepsy of Lafora pathway
MPS II - Hunter syndrome pathway
A tetrasaccharide linker sequence is required for GAG synthesis pathway
MPS VII - Sly syndrome pathway
Visual phototransduction pathway
Defective B3GAT3 causes JDSSDHD pathway
Mucopolysaccharidoses pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Diseases of glycosylation pathway
HS-GAG degradation pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Metabolism of lipids and lipoproteins pathway
MPS IIIC - Sanfilippo syndrome C pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
Defective CHST3 causes SEDCJD pathway
Metabolism pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective SLC26A2 causes chondrodysplasias pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome A pathway
Syndecan interactions pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
MPS IV - Morquio syndrome B pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Disease pathway
Lipid digestion, mobilization, and transport pathway
HS-GAG biosynthesis pathway
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| KEGG | |||||||||||||||
| INOH | |||||||||||||||
| PID NCI | |||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||
| NETPATH |
EGFR1 pathway
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| REACTOME |
Retinoid metabolism and transport pathway
Chylomicron-mediated lipid transport pathway
A tetrasaccharide linker sequence is required for GAG synthesis pathway
HS-GAG degradation pathway
HS-GAG biosynthesis pathway
Metabolism of lipids and lipoproteins pathway
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Extracellular matrix organization pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Syndecan interactions pathway
Defective SLC26A2 causes chondrodysplasias pathway
Signal Transduction pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
Diseases associated with visual transduction pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Non-integrin membrane-ECM interactions pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Visual phototransduction pathway
Glycosaminoglycan metabolism pathway
Lipoprotein metabolism pathway
Diseases of glycosylation pathway
Chondroitin sulfate/dermatan sulfate metabolism pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Lipid digestion, mobilization, and transport pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
Glycosaminoglycan metabolism pathway
Syndecan interactions pathway
Disease pathway
Retinoid metabolism and transport pathway
HS-GAG degradation pathway
MPS IV - Morquio syndrome B pathway
MPS IV - Morquio syndrome A pathway
Chondroitin sulfate/dermatan sulfate metabolism pathway
MPS IIIC - Sanfilippo syndrome C pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
Extracellular matrix organization pathway
MPS IIID - Sanfilippo syndrome D pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Diseases of glycosylation pathway
Metabolism of lipids and lipoproteins pathway
Defective CHSY1 causes TPBS pathway
Defective B3GAT3 causes JDSSDHD pathway
MPS II - Hunter syndrome pathway
Diseases associated with glycosaminoglycan metabolism pathway
Lipid digestion, mobilization, and transport pathway
A tetrasaccharide linker sequence is required for GAG synthesis pathway
HS-GAG biosynthesis pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
MPS IX - Natowicz syndrome pathway
Chylomicron-mediated lipid transport pathway
Lipoprotein metabolism pathway
Glycogen storage diseases pathway
MPS VII - Sly syndrome pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Defective CHST3 causes SEDCJD pathway
Non-integrin membrane-ECM interactions pathway
Visual phototransduction pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
MPS IIIB - Sanfilippo syndrome B pathway
MPS IIIA - Sanfilippo syndrome A pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Defective PAPSS2 causes SEMD-PA pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Mucopolysaccharidoses pathway
Defective CHST6 causes MCDC1 pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Defective EXT2 causes exostoses 2 pathway
Defective SLC26A2 causes chondrodysplasias pathway
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| KEGG |
Cell adhesion molecules (CAMs) pathway
ECM-receptor interaction pathway
Malaria pathway
Cell adhesion molecules (CAMs) pathway
ECM-receptor interaction pathway
Malaria pathway
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| INOH |
Integrin signaling pathway pathway
Wnt signaling pathway pathway
Integrin signaling pathway pathway
Wnt signaling pathway pathway
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| PID NCI |
Proteoglycan syndecan-mediated signaling events
Integrins in angiogenesis
Beta3 integrin cell surface interactions
Syndecan-1-mediated signaling events
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
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| Cross-References | |||||||||||||||
| SwissProt | |||||||||||||||
| TrEMBL | |||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | |||||||||||||||
| UniGene | Bt.46190 | ||||||||||||||
| RefSeq | NM_001075924 | ||||||||||||||
| HUGO | |||||||||||||||
| OMIM | |||||||||||||||
| CCDS | |||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| EMBL | |||||||||||||||
| GenPept | |||||||||||||||
| RNA Seq Atlas | |||||||||||||||