Version 5.4
Mus musculus Gene: Sdc1
Summary
InnateDB Gene IDBG-128466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sdc1
Gene Name syndecan 1
Synonyms AA408134; AA409076; CD138; Sstn; syn-1; Synd; Synd1
Species Mus musculus
Ensembl Gene ENSMUSG00000020592
Encoded Proteins
IDBP-128468
syndecan 1
IDBP-541158
syndecan 1
IDBP-623005
syndecan 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115884:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8771323-8793715
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000020911 ENSMUSP00000020911
ENSMUST00000159821
ENSMUST00000161883 ENSMUSP00000123896
ENSMUST00000160348
ENSMUST00000171158 ENSMUSP00000131491
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0001657 ureteric bud development
GO:0006954 inflammatory response
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0042060 wound healing
GO:0042476 odontogenesis
GO:0042542 response to hydrogen peroxide
GO:0048627 myoblast development
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0055002 striated muscle cell development
GO:0060009 Sertoli cell development
GO:0060070 canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005796 Golgi lumen
GO:0005925 focal adhesion
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115884
View Gene Order
ENSBTAG00000011154
Not yet available
Pathways
NETPATH
REACTOME
REACT_222247
Glycosaminoglycan metabolism pathway
REACT_196644
Syndecan interactions pathway
REACT_189085
Disease pathway
REACT_198569
Retinoid metabolism and transport pathway
REACT_198967
HS-GAG degradation pathway
REACT_211754
MPS IV - Morquio syndrome B pathway
REACT_225132
MPS IV - Morquio syndrome A pathway
REACT_198988
Chondroitin sulfate/dermatan sulfate metabolism pathway
REACT_218935
MPS IIIC - Sanfilippo syndrome C pathway
REACT_188937
Metabolism pathway
REACT_224474
MPS I - Hurler syndrome pathway
REACT_206066
Extracellular matrix organization pathway
REACT_227993
MPS IIID - Sanfilippo syndrome D pathway
REACT_269282
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_270278
Diseases of glycosylation pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_268957
Defective CHSY1 causes TPBS pathway
REACT_268952
Defective B3GAT3 causes JDSSDHD pathway
REACT_215504
MPS II - Hunter syndrome pathway
REACT_269263
Diseases associated with glycosaminoglycan metabolism pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_196489
A tetrasaccharide linker sequence is required for GAG synthesis pathway
REACT_198654
HS-GAG biosynthesis pathway
REACT_198651
Heparan sulfate/heparin (HS-GAG) metabolism pathway
REACT_219946
MPS IX - Natowicz syndrome pathway
REACT_216017
Chylomicron-mediated lipid transport pathway
REACT_211709
Lipoprotein metabolism pathway
REACT_203949
Glycogen storage diseases pathway
REACT_208416
MPS VII - Sly syndrome pathway
REACT_271176
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_269050
Defective CHST3 causes SEDCJD pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_188260
Visual phototransduction pathway
REACT_215179
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_268667
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_221180
MPS IIIB - Sanfilippo syndrome B pathway
REACT_221189
MPS IIIA - Sanfilippo syndrome A pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
REACT_270086
Defective PAPSS2 causes SEMD-PA pathway
REACT_271374
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_217438
Mucopolysaccharidoses pathway
REACT_269577
Defective CHST6 causes MCDC1 pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
REACT_270174
Defective EXT2 causes exostoses 2 pathway
REACT_269276
Defective SLC26A2 causes chondrodysplasias pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04512
ECM-receptor interaction pathway
mmu05144
Malaria pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Wnt signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_6841
Chylomicron-mediated lipid transport pathway
REACT_121408
A tetrasaccharide linker sequence is required for GAG synthesis pathway
REACT_120752
HS-GAG degradation pathway
REACT_121248
HS-GAG biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_118779
Extracellular matrix organization pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_163942
Syndecan interactions pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_111102
Signal Transduction pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_121314
Heparan sulfate/heparin (HS-GAG) metabolism pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_160125
Visual phototransduction pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_6823
Lipoprotein metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_121206
Chondroitin sulfate/dermatan sulfate metabolism pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
REACT_269304
Defective EXT2 causes exostoses 2 pathway
REACT_269658
Defective CHST6 causes MCDC1 pathway
REACT_216637
MPS IIIA - Sanfilippo syndrome A pathway
REACT_271434
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_268431
Defective PAPSS2 causes SEMD-PA pathway
REACT_221274
Metabolism of carbohydrates pathway
REACT_205556
Glycosaminoglycan metabolism pathway
REACT_219927
Non-integrin membrane-ECM interactions pathway
REACT_270533
Defective CHSY1 causes TPBS pathway
REACT_208011
Chondroitin sulfate/dermatan sulfate metabolism pathway
REACT_204212
MPS I - Hurler syndrome pathway
REACT_224609
MPS IIID - Sanfilippo syndrome D pathway
REACT_268552
Diseases associated with glycosaminoglycan metabolism pathway
REACT_206940
Chylomicron-mediated lipid transport pathway
REACT_223425
Extracellular matrix organization pathway
REACT_204227
Retinoid metabolism and transport pathway
REACT_226837
MPS IX - Natowicz syndrome pathway
REACT_212432
Lipoprotein metabolism pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_208504
MPS II - Hunter syndrome pathway
REACT_224088
A tetrasaccharide linker sequence is required for GAG synthesis pathway
REACT_220414
MPS VII - Sly syndrome pathway
REACT_223698
Visual phototransduction pathway
REACT_268766
Defective B3GAT3 causes JDSSDHD pathway
REACT_208051
Mucopolysaccharidoses pathway
REACT_214353
Signal Transduction pathway
REACT_216038
Diseases associated with visual transduction pathway
REACT_268446
Diseases of glycosylation pathway
REACT_202491
HS-GAG degradation pathway
REACT_271537
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_220816
MPS IIIC - Sanfilippo syndrome C pathway
REACT_211129
Glycogen storage diseases pathway
REACT_212403
MPS IIIB - Sanfilippo syndrome B pathway
REACT_270161
Defective CHST3 causes SEDCJD pathway
REACT_219139
Metabolism pathway
REACT_269058
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_269825
Defective SLC26A2 causes chondrodysplasias pathway
REACT_270962
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_218915
MPS IV - Morquio syndrome A pathway
REACT_204848
Syndecan interactions pathway
REACT_206992
Heparan sulfate/heparin (HS-GAG) metabolism pathway
REACT_217121
MPS IV - Morquio syndrome B pathway
REACT_215576
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_207087
Disease pathway
REACT_213267
Lipid digestion, mobilization, and transport pathway
REACT_218445
HS-GAG biosynthesis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04512
ECM-receptor interaction pathway
hsa05144
Malaria pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Wnt signaling pathway pathway
PID NCI
syndecan_pathway
Proteoglycan syndecan-mediated signaling events
avb3_integrin_pathway
Integrins in angiogenesis
integrin3_pathway
Beta3 integrin cell surface interactions
syndecan_1_pathway
Syndecan-1-mediated signaling events
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.2580 Mm.436389
RefSeq NM_011519 XM_006515045 XM_006515046
OMIM
CCDS CCDS25803
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca