InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FBL

Summary

InnateDB Gene

IDBG-637678.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBL

Gene Name

rRNA 2'-O-methyltransferase fibrillarin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002579

Encoded Proteins

IDBP-689766

FBL protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105202:
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8%% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:49659188-49718941

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003340

ENSBTAP00000003340

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 94 interaction(s) predicted by orthology.

Predicted by orthology
Total	94 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0044822	poly(A) RNA binding
GO:1990259	histone-glutamine methyltransferase activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0006364	rRNA processing
GO:0008033	tRNA processing
GO:0016074	snoRNA metabolic process
GO:0032259	methylation
GO:1990258	histone glutamine methylation

Cellular Component

GO:0001652	granular component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0015030	Cajal body
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000105202

View Gene Order

ENSMUSG00000046865

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001205400

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas