InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBL

Summary

InnateDB Gene

IDBG-50843.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBL

Gene Name

fibrillarin

Synonyms

FIB; FLRN; RNU3IP1

Species

Homo sapiens

Ensembl Gene

ENSG00000105202

Encoded Proteins

IDBP-50845

fibrillarin

IDBP-761792

IDBP-760772

IDBP-764971

IDBP-762590

IDBP-765144

IDBP-766170

IDBP-765156

IDBP-766269

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8%% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:39834458-39846414

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000221801	ENSP00000221801
ENST00000599159
ENST00000598417	ENSP00000471867
ENST00000593503
ENST00000594309	ENSP00000472433
ENST00000597634	ENSP00000471350
ENST00000594443	ENSP00000469072
ENST00000597224	ENSP00000469249
ENST00000599134	ENSP00000472805
ENST00000601274	ENSP00000472726
ENST00000595545	ENSP00000472419

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.

Experimentally validated
Total	136 [view]
Protein-Protein	135 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity
GO:0044822	poly(A) RNA binding
GO:1990259	histone-glutamine methyltransferase activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0006364	rRNA processing
GO:0008033	tRNA processing
GO:0016074	snoRNA metabolic process
GO:0030488	tRNA methylation
GO:0032259	methylation
GO:1990258	histone glutamine methylation

Cellular Component

GO:0001652	granular component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0015030	Cajal body
GO:0016020	membrane
GO:0031428	box C/D snoRNP complex
GO:0031515	tRNA (m1A) methyltransferase complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000046865

View Gene Order

ENSBTAG00000002579

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

M0R0P1

UniProt Splice Variant

Entrez Gene

2091

UniGene

Hs.626441

RefSeq

NM_001436 XM_005258651

HUGO

HGNC:3599

OMIM

134795

CCDS

CCDS12545

HPRD

00617

IMGT

EMBL

AC005393 AC006950

GenPept

RNA Seq Atlas

2091