Bos taurus Gene: MAPK7 | |||||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-637775.3 | ||||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||
Gene Symbol | MAPK7 | ||||||||||||||||||||||||||||||||||||||||
Gene Name | Mitogen-activated protein kinase 7 | ||||||||||||||||||||||||||||||||||||||||
Synonyms | ERK-5 | ||||||||||||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000001014 | ||||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
Mitogen-activated protein kinase 7
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Protein Structure | |||||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166484:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 19:34687988-34693036 | ||||||||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||||||
REACTOME |
ERKs are inactivated pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Signaling by GPCR pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88-independent cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Cellular responses to stress pathway
Immune System pathway
MAP kinase activation in TLR cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
Nuclear Events (kinase and transcription factor activation) pathway
Cellular Senescence pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Signalling by NGF pathway
ERK/MAPK targets pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MyD88 dependent cascade initiated on endosome pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Innate Immune System pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Signalling to ERK5 pathway
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KEGG | |||||||||||||||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||
NETPATH |
EGFR1 pathway
TCR pathway
Prolactin pathway
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REACTOME |
ERKs are inactivated pathway
ERK/MAPK targets pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Signalling to ERK5 pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Cellular responses to stress pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Signaling by GPCR pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Cellular Senescence pathway
NGF signalling via TRKA from the plasma membrane pathway
Activated TLR4 signalling pathway
Nuclear Events (kinase and transcription factor activation) pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
ERKs are inactivated pathway
Signaling by GPCR pathway
Cellular responses to stress pathway
MyD88 cascade initiated on plasma membrane pathway
ERK/MAPK targets pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Signalling to ERK5 pathway
Cellular Senescence pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Signalling by NGF pathway
Activated TLR4 signalling pathway
NGF signalling via TRKA from the plasma membrane pathway
MyD88-independent cascade pathway
Signal Transduction pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Nuclear Events (kinase and transcription factor activation) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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KEGG |
GnRH signaling pathway pathway
Gap junction pathway
MAPK signaling pathway pathway
Neurotrophin signaling pathway pathway
Gap junction pathway
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Neurotrophin signaling pathway pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
TGF-beta signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
TGF-beta signaling pathway
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PID NCI |
Trk receptor signaling mediated by the MAPK pathway
ErbB1 downstream signaling
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Cross-References | |||||||||||||||||||||||||||||||||||||||||
SwissProt | A5PKJ4 | ||||||||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||
Entrez Gene | 537703 | ||||||||||||||||||||||||||||||||||||||||
UniGene | Bt.103114 | ||||||||||||||||||||||||||||||||||||||||
RefSeq | NM_001099080 XM_005220383 XM_005220384 | ||||||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||||
EMBL | BC142510 | ||||||||||||||||||||||||||||||||||||||||
GenPept | AAI42511 | ||||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 537703 | ||||||||||||||||||||||||||||||||||||||||