Version 5.4
Homo sapiens Gene: MAPK7
Summary
InnateDB Gene IDBG-34638.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK7
Gene Name mitogen-activated protein kinase 7
Synonyms BMK1; ERK4; ERK5; PRKM7
Species Homo sapiens
Ensembl Gene ENSG00000166484
Encoded Proteins
IDBP-34640
mitogen-activated protein kinase 7
IDBP-34642
mitogen-activated protein kinase 7
IDBP-239210
mitogen-activated protein kinase 7
IDBP-239212
mitogen-activated protein kinase 7
IDBP-372376
mitogen-activated protein kinase 7
IDBP-757909
IDBP-757802
IDBP-760457
IDBP-812585
mitogen-activated protein kinase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:19377721-19383544
Strand Forward strand
Band p11.2
Transcripts
ENST00000299612 ENSP00000299612
ENST00000308406 ENSP00000311005
ENST00000395604 ENSP00000378968
ENST00000395602 ENSP00000378966
ENST00000443215 ENSP00000412902
ENST00000490660
ENST00000482850 ENSP00000458146
ENST00000486905
ENST00000572716
ENST00000572968
ENST00000572853
ENST00000581260 ENSP00000462804
ENST00000573417
ENST00000570306
ENST00000573466
ENST00000571657
ENST00000579284 ENSP00000462819
ENST00000603493 ENSP00000474397
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
Experimentally validated
Total 75 [view]
Protein-Protein 71 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0051019 mitogen-activated protein kinase binding
Biological Process
GO:0000165 MAPK cascade
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0018105 peptidyl-serine phosphorylation
GO:0019933 cAMP-mediated signaling
GO:0030154 cell differentiation
GO:0030821 negative regulation of cAMP catabolic process
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response
GO:0045765 regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0051247 positive regulation of protein metabolic process
GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051403 stress-activated MAPK cascade
GO:0051534 negative regulation of NFAT protein import into nucleus
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070301 cellular response to hydrogen peroxide
GO:0071363 cellular response to growth factor stimulus
GO:0071499 cellular response to laminar fluid shear stress
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016605 PML body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001034
View Gene Order
ENSBTAG00000001014
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_12436
ERKs are inactivated pathway
REACT_12599
ERK/MAPK targets pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_12020
Signalling to ERK5 pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_120956
Cellular responses to stress pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04540
Gap junction pathway
hsa04010
MAPK signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TGF-beta signaling pathway
PID NCI
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
erbb1_downstream_pathway
ErbB1 downstream signaling
Cross-References
SwissProt
TrEMBL J3KT61
UniProt Splice Variant
Entrez Gene 5598
UniGene Hs.150136
RefSeq NM_002749 NM_139032 NM_139033 NM_139034 XM_005256719 XM_006721557 XM_006721558 XM_006721559 XM_006721560
HUGO HGNC:6880
OMIM 602521
CCDS CCDS11206 CCDS11207
HPRD 03952
IMGT
EMBL AC124066
GenPept
RNA Seq Atlas 5598

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca