Version 5.4
Bos taurus Gene: PGHS-2
Summary
InnateDB Gene IDBG-637781.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGHS-2
Gene Name prostaglandin G/H synthase 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014127
Encoded Proteins
IDBP-689806
prostaglandin G/H synthase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18955820
[Homo sapiens] PTGS2 (COX-2) is suppressed through inhibiting the NF-kappaB activation by LPS and this may be associated with the anti-inflammatory effects of L. casei on Raw264.7 cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073756:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:69263776-69271399
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018774 ENSBTAP00000018774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0006979 response to oxidative stress
GO:0008217 regulation of blood pressure
GO:0019371 cyclooxygenase pathway
GO:0031622 positive regulation of fever generation
GO:0042127 regulation of cell proliferation
GO:0042640 anagen
GO:0050873 brown fat cell differentiation
GO:0055114 oxidation-reduction process
GO:0071456 cellular response to hypoxia
GO:0090336 positive regulation of brown fat cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000073756
View Gene Order
ENSMUSG00000032487
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150422
Synthesis of 15-eicosatetraenoic acid derivatives pathway
REACT_150149
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_11213
Nicotinamide salvaging pathway
REACT_11088
Nicotinate metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
REACT_189088
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_189085
Disease pathway
REACT_211619
Nicotinamide salvaging pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_189089
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_189086
Defective GIF causes intrinsic factor deficiency pathway
REACT_189075
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_189076
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_189078
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_189098
Defective CD320 causes methylmalonic aciduria pathway
REACT_189097
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_189096
Defects in biotin (Btn) metabolism pathway
REACT_189095
Defective BTD causes biotidinase deficiency pathway
REACT_189093
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_189092
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_189091
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_189090
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_254651
Metabolism of vitamins and cofactors pathway
REACT_238663
Metabolism of water-soluble vitamins and cofactors pathway
REACT_196559
Synthesis of 15-eicosatetraenoic acid derivatives pathway
REACT_209575
Nicotinate metabolism pathway
REACT_188623
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_189110
Defects in vitamin and cofactor metabolism pathway
REACT_189116
Defects in cobalamin (B12) metabolism pathway
REACT_189114
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_188625
Arachidonic acid metabolism pathway
REACT_189100
Defective HLCS causes multiple carboxylase deficiency pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
hsa04370
VEGF signaling pathway pathway
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
hsa05140
Leishmaniasis pathway
mmu04370
VEGF signaling pathway pathway
mmu00590
Arachidonic acid metabolism pathway
mmu05222
Small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
mmu05140
Leishmaniasis pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
s1p_s1p1_pathway
S1P1 pathway
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
cmyb_pathway
C-MYB transcription factor network
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL F1MNI5 Q9TVB3
UniProt Splice Variant
Entrez Gene 282023
UniGene Bt.112336 Bt.15758
RefSeq NM_174445
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF145750 DAAA02043637
GenPept AAD33956
RNA Seq Atlas 282023

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca