Version 5.4
Bos taurus Protein: PGHS-2
Summary
InnateDB Protein IDBP-689806.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGHS-2
Protein Name prostaglandin G/H synthase 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018774
InnateDB Gene IDBG-637781 (PGHS-2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0006979 response to oxidative stress
GO:0008217 regulation of blood pressure
GO:0019371 cyclooxygenase pathway
GO:0031622 positive regulation of fever generation
GO:0042127 regulation of cell proliferation
GO:0042640 anagen
GO:0050873 brown fat cell differentiation
GO:0055114 oxidation-reduction process
GO:0071456 cellular response to hypoxia
GO:0090336 positive regulation of brown fat cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0043005 neuron projection
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
IPR010255 Haem peroxidase
IPR019791 Haem peroxidase, animal
PFAM PF00008
PF03098
PRINTS PR00457
PIRSF
SMART SM00181
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9TVB3
UniProt Splice Variant
Entrez Gene 282023
UniGene Bt.15758
RefSeq NP_776870
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF145750 DAAA02043637
GenPept AAD33956

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca