Version 5.4
Bos taurus Gene: MUSK
Summary
InnateDB Gene IDBG-637783.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUSK
Gene Name muscle, skeletal receptor tyrosine-protein kinase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002744
Encoded Proteins
IDBP-689860
muscle, skeletal, receptor tyrosine kinase
IDBP-689862
muscle, skeletal, receptor tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000030304:
This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:101881883-101976250
Strand Forward strand
Band
Transcripts
ENSBTAT00000003558 ENSBTAP00000003558
ENSBTAT00000065708 ENSBTAP00000054959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030165 PDZ domain binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007528 neuromuscular junction development
GO:0008582 regulation of synaptic growth at neuromuscular junction
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043113 receptor clustering
GO:0043525 positive regulation of neuron apoptotic process
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:2000541 positive regulation of protein geranylgeranylation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031594 neuromuscular junction
GO:0043235 receptor complex
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000030304
View Gene Order
ENSMUSG00000057280
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_163906
ECM proteoglycans pathway
REACT_206066
Extracellular matrix organization pathway
REACT_196606
ECM proteoglycans pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.56811
RefSeq NM_001192352
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca