Version 5.4
Mus musculus Gene: Musk
Summary
InnateDB Gene IDBG-150212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Musk
Gene Name muscle, skeletal, receptor tyrosine kinase
Synonyms Mdk4; Mlk; Nsk1; Nsk2; Nsk3
Species Mus musculus
Ensembl Gene ENSMUSG00000057280
Encoded Proteins
IDBP-150214
muscle, skeletal, receptor tyrosine kinase
IDBP-150216
muscle, skeletal, receptor tyrosine kinase
IDBP-150218
muscle, skeletal, receptor tyrosine kinase
IDBP-150220
muscle, skeletal, receptor tyrosine kinase
IDBP-150222
muscle, skeletal, receptor tyrosine kinase
IDBP-718245
IDBP-717160
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:58285960-58374303
Strand Forward strand
Band B3
Transcripts
ENSMUST00000098059 ENSMUSP00000095667
ENSMUST00000098057 ENSMUSP00000095665
ENSMUST00000081919 ENSMUSP00000080590
ENSMUST00000084578 ENSMUSP00000081625
ENSMUST00000102893 ENSMUSP00000099957
ENSMUST00000135879
ENSMUST00000177951 ENSMUSP00000136696
ENSMUST00000179951 ENSMUSP00000137453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030165 PDZ domain binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007275 multicellular organismal development
GO:0007528 neuromuscular junction development
GO:0008582 regulation of synaptic growth at neuromuscular junction
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0043113 receptor clustering
GO:0043525 positive regulation of neuron apoptotic process
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:2000541 positive regulation of protein geranylgeranylation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0030054 cell junction
GO:0031594 neuromuscular junction
GO:0043235 receptor complex
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000030304
View Gene Order
ENSBTAG00000002744
Not yet available
Pathways
NETPATH
REACTOME
REACT_206066
Extracellular matrix organization pathway
REACT_196606
ECM proteoglycans pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_163906
ECM proteoglycans pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL J3QPS3 Q8K3G6
UniProt Splice Variant
Entrez Gene 18198
UniGene Mm.16148
RefSeq NM_001037127 NM_001037128 NM_001037129 NM_001037130 NM_010944
OMIM
CCDS CCDS18210 CCDS18211 CCDS38770 CCDS51182
HPRD
IMGT
MGI ID MGI:103581
MGI Symbol Musk
EMBL AL805969 AL807748 AY114512
GenPept AAM66750
RNA Seq Atlas 18198

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca