InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GAD2

Summary

InnateDB Gene

IDBG-637846.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAD2

Gene Name

glutamate decarboxylase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008056

Encoded Proteins

IDBP-689923

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136750:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:26937414-26999001

Strand

Forward strand

Band

Transcripts

ENSBTAT00000010598

ENSBTAP00000010598

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding