InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gad2

Summary

InnateDB Gene

IDBG-141187.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gad2

Gene Name

glutamic acid decarboxylase 2

Synonyms

6330404F12Rik; Gad-2; GAD(65); GAD65

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026787

Encoded Proteins

IDBP-141189

glutamic acid decarboxylase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136750:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:22622205-22693874

Strand

Forward strand

Band

Transcripts

ENSMUST00000028123	ENSMUSP00000028123
ENSMUST00000156728

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004351	glutamate decarboxylase activity
GO:0005515	protein binding
GO:0016595	glutamate binding
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006540	glutamate decarboxylation to succinate
GO:0019752	carboxylic acid metabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042493	response to drug

Cellular Component

GO:0000139	Golgi membrane
GO:0005829	cytosol
GO:0030054	cell junction
GO:0030424	axon
GO:0030672	synaptic vesicle membrane
GO:0031225	anchored component of membrane
GO:0031410	cytoplasmic vesicle
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm