Version 5.4
Bos taurus Gene: BT.103042
Summary
InnateDB Gene IDBG-637851.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.103042
Gene Name DNA topoisomerase 3-alpha
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017087
Encoded Proteins
IDBP-689891
DNA topoisomerase 3-alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177302:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:34961467-34981886
Strand Forward strand
Band
Transcripts
ENSBTAT00000022721 ENSBTAP00000022721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016853 isomerase activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000177302
View Gene Order
ENSMUSG00000002814
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
REACT_27235
Meiotic Recombination pathway
REACT_200794
Mus musculus biological processes pathway
REACT_188804
Cell Cycle pathway
REACT_198624
Meiosis pathway
REACT_198629
Meiotic recombination pathway
KEGG
hsa03440
Homologous recombination pathway
mmu03440
Homologous recombination pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atm_pathway
ATM pathway
Cross-References
SwissProt
TrEMBL F1MGY1
UniProt Splice Variant
Entrez Gene 527411
UniGene Bt.103042
RefSeq NM_001077975
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02048987 DAAA02048988
GenPept
RNA Seq Atlas 527411

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca