Version 5.4
Mus musculus Gene: Top3a
Summary
InnateDB Gene IDBG-181695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Top3a
Gene Name topoisomerase (DNA) III alpha
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000002814
Encoded Proteins
IDBP-181697
topoisomerase (DNA) III alpha
IDBP-181699
topoisomerase (DNA) III alpha
IDBP-400419
topoisomerase (DNA) III alpha
IDBP-400415
topoisomerase (DNA) III alpha
IDBP-540667
topoisomerase (DNA) III alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177302:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:60740058-60777365
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000102668 ENSMUSP00000099729
ENSMUST00000002891 ENSMUSP00000002891
ENSMUST00000117743 ENSMUSP00000113057
ENSMUST00000120417 ENSMUSP00000113653
ENSMUST00000124799
ENSMUST00000130068 ENSMUSP00000115727
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177302
View Gene Order
ENSBTAG00000017087
Not yet available
Pathways
NETPATH
REACTOME
REACT_27235
Meiotic Recombination pathway
REACT_200794
Mus musculus biological processes pathway
REACT_188804
Cell Cycle pathway
REACT_198624
Meiosis pathway
REACT_198629
Meiotic recombination pathway
KEGG
mmu03440
Homologous recombination pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
hsa03440
Homologous recombination pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atm_pathway
ATM pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.477819
RefSeq NM_009410
OMIM
CCDS CCDS24797
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca