Version 5.4
| Bos taurus Gene: PRKAG2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-637857.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PRKAG2 | ||||||||||||||||||
| Gene Name | Uncharacterized protein | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||
| Ensembl Gene | ENSBTAG00000002917 | ||||||||||||||||||
| Encoded Proteins |
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106617:
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 4:114885501-114925565 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | |||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Regulation of Rheb GTPase activity by AMPK pathway
Regulation of AMPK activity via LKB1 pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
AMPK inhibits chREBP transcriptional activation activity pathway
Integration of energy metabolism pathway
Translocation of GLUT4 to the plasma membrane pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Organelle biogenesis and maintenance pathway
Metabolism of lipids and lipoproteins pathway
PKB-mediated events pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
Mitochondrial biogenesis pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Metabolism pathway
Membrane Trafficking pathway
Organelle biogenesis and maintenance pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Regulation of AMPK activity via LKB1 pathway
Signaling by Insulin receptor pathway
Integration of energy metabolism pathway
Membrane Trafficking pathway
Metabolism pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Metabolism of lipids and lipoproteins pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Regulation of Rheb GTPase activity by AMPK pathway
PI3K Cascade pathway
AMPK inhibits chREBP transcriptional activation activity pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
IRS-related events pathway
IRS-mediated signalling pathway
Signal Transduction pathway
Mitochondrial biogenesis pathway
mTOR signalling pathway
PKB-mediated events pathway
Translocation of GLUT4 to the plasma membrane pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
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| KEGG |
Circadian rhythm pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Hypertrophic cardiomyopathy (HCM) pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Circadian rhythm pathway
Hypertrophic cardiomyopathy (HCM) pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | F1MFX9 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 504219 | ||||||||||||||||||
| UniGene | Bt.42860 | ||||||||||||||||||
| RefSeq | XM_002686979 XM_002704191 XM_005198176 XM_005198177 XM_005198178 XM_005198179 XM_005198181 XM_005198182 XM_005198183 | ||||||||||||||||||
| HUGO | HGNC:9386 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | DAAA02012032 DAAA02012033 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 504219 | ||||||||||||||||||