InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKAG2

Summary

InnateDB Gene

IDBG-49672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKAG2

Gene Name

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000106617

Encoded Proteins

IDBP-49674

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

IDBP-244911

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

IDBP-387421

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

IDBP-476284

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

IDBP-480429

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

IDBP-483069

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

IDBP-475788

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

IDBP-484720

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:151556111-151877125

Strand

Reverse strand

Band

q36.1

Transcripts

ENST00000287878	ENSP00000287878
ENST00000392801	ENSP00000376549
ENST00000418337	ENSP00000387386
ENST00000492843	ENSP00000419577
ENST00000479461
ENST00000485183
ENST00000478989	ENSP00000420645
ENST00000488258	ENSP00000420783
ENST00000476632	ENSP00000419493
ENST00000493872	ENSP00000417252
ENST00000491938
ENST00000483775
ENST00000481434
ENST00000487375
ENST00000461529
ENST00000474383

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004679	AMP-activated protein kinase activity
GO:0004862	cAMP-dependent protein kinase inhibitor activity
GO:0005524	ATP binding
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0008607	phosphorylase kinase regulator activity
GO:0016208	AMP binding
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity
GO:0030554	adenyl nucleotide binding
GO:0043531	ADP binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0006110	regulation of glycolytic process
GO:0006112	energy reserve metabolic process
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0006633	fatty acid biosynthetic process
GO:0006754	ATP biosynthetic process
GO:0006853	carnitine shuttle
GO:0007050	cell cycle arrest
GO:0008286	insulin receptor signaling pathway
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0016126	sterol biosynthetic process
GO:0019217	regulation of fatty acid metabolic process
GO:0035556	intracellular signal transduction
GO:0042304	regulation of fatty acid biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045860	positive regulation of protein kinase activity
GO:0046320	regulation of fatty acid oxidation
GO:0046324	regulation of glucose import
GO:0050790	regulation of catalytic activity
GO:0061024	membrane organization
GO:0071901	negative regulation of protein serine/threonine kinase activity