Version 5.4
Bos taurus Gene: MED15
Summary
InnateDB Gene IDBG-637891.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED15
Gene Name mediator of RNA polymerase II transcription subunit 15
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018048
Encoded Proteins
IDBP-689931
mediator of RNA polymerase II transcription subunit 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099917:
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74425042-74490537
Strand Reverse strand
Band
Transcripts
ENSBTAT00000029374 ENSBTAP00000029374
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
Predicted by orthology
Total 55 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0005515 protein binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0019827 stem cell maintenance
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0016592 mediator complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000099917
View Gene Order
ENSMUSG00000012114
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL A5PKJ6
UniProt Splice Variant
Entrez Gene 618232
UniGene Bt.10890 Bt.55308
RefSeq NM_001099175 XM_005218271
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142512 DAAA02045744 DAAA02045745 DAAA02045746 DAAA02045747 DAAA02045748
GenPept AAI42513
RNA Seq Atlas 618232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca