Version 5.4
Homo sapiens Gene: MED15
Summary
InnateDB Gene IDBG-1757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED15
Gene Name mediator complex subunit 15
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000099917
Encoded Proteins
IDBP-1759
mediator complex subunit 15
IDBP-1761
mediator complex subunit 15
IDBP-1763
mediator complex subunit 15
IDBP-292609
mediator complex subunit 15
IDBP-363409
mediator complex subunit 15
IDBP-363417
mediator complex subunit 15
IDBP-363425
mediator complex subunit 15
IDBP-363453
mediator complex subunit 15
IDBP-363461
mediator complex subunit 15
IDBP-363565
mediator complex subunit 15
IDBP-363568
mediator complex subunit 15
IDBP-363573
mediator complex subunit 15
IDBP-363577
mediator complex subunit 15
IDBP-363583
mediator complex subunit 15
IDBP-363585
mediator complex subunit 15
IDBP-363589
mediator complex subunit 15
IDBP-363591
mediator complex subunit 15
IDBP-363593
mediator complex subunit 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:20495913-20587632
Strand Forward strand
Band q11.21
Transcripts
ENST00000263205 ENSP00000263205
ENST00000292733 ENSP00000292733
ENST00000382974 ENSP00000372434
ENST00000406969 ENSP00000384344
ENST00000445987 ENSP00000407742
ENST00000444094 ENSP00000409578
ENST00000414658 ENSP00000392738
ENST00000433831 ENSP00000391108
ENST00000432052 ENSP00000408794
ENST00000441501 ENSP00000413636
ENST00000438962 ENSP00000410173
ENST00000445189 ENSP00000390498
ENST00000451058 ENSP00000408742
ENST00000457322 ENSP00000415778
ENST00000428629 ENSP00000413603
ENST00000424287 ENSP00000396461
ENST00000423862 ENSP00000408875
ENST00000420849 ENSP00000416109
ENST00000436496
ENST00000486656
ENST00000477824
ENST00000473028
ENST00000487550
ENST00000476767
ENST00000492381
ENST00000478831
ENST00000489651
ENST00000473244
ENST00000493216
ENST00000476187
ENST00000461076
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 74 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0005515 protein binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0019827 stem cell maintenance
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000012114
View Gene Order
ENSBTAG00000018048
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517421
RefSeq NM_001003891 NM_001293235 NM_001293236 NM_001293237 NM_015889 XM_005261632 XM_006724261 XM_006724262 XM_006724264
HUGO
OMIM
CCDS CCDS13781 CCDS33602 CCDS74824
HPRD 12117
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca