Version 5.4
Bos taurus Gene: BT.20369
Summary
InnateDB Gene IDBG-637904.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.20369
Gene Name proline dehydrogenase 1, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000047676
Encoded Proteins
IDBP-689946
proline dehydrogenase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100033:
This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74439064-74456082
Strand Reverse strand
Band
Transcripts
ENSBTAT00000062994 ENSBTAP00000056646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004657 proline dehydrogenase activity
Biological Process
GO:0006537 glutamate biosynthetic process
GO:0006562 proline catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100033
View Gene Order
ENSMUSG00000003526
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1002
Proline catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_255384
Proline catabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
mmu00330
Arginine and proline metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3N3Y2
UniProt Splice Variant
Entrez Gene 505094
UniGene Bt.20369
RefSeq NM_001075185
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02045746 DAAA02045747
GenPept
RNA Seq Atlas 505094
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca