Version 5.4
Homo sapiens Gene: PRODH
Summary
InnateDB Gene IDBG-1197.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRODH
Gene Name proline dehydrogenase (oxidase) 1
Synonyms HSPOX2; PIG6; POX; PRODH1; PRODH2; TP53I6
Species Homo sapiens
Ensembl Gene ENSG00000100033
Encoded Proteins
IDBP-1199
proline dehydrogenase (oxidase) 1
IDBP-1201
proline dehydrogenase (oxidase) 1
IDBP-361430
proline dehydrogenase (oxidase) 1
IDBP-361448
proline dehydrogenase (oxidase) 1
IDBP-361450
proline dehydrogenase (oxidase) 1
IDBP-361451
proline dehydrogenase (oxidase) 1
IDBP-809369
proline dehydrogenase (oxidase) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:18912777-18936553
Strand Reverse strand
Band q11.21
Transcripts
ENST00000334029 ENSP00000334726
ENST00000357068 ENSP00000349577
ENST00000313755
ENST00000399694
ENST00000420436 ENSP00000410805
ENST00000429300
ENST00000446371
ENST00000438924 ENSP00000409742
ENST00000450579 ENSP00000396806
ENST00000457083 ENSP00000413941
ENST00000491604
ENST00000482858
ENST00000496625
ENST00000609229
ENST00000610940 ENSP00000480347
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004657 proline dehydrogenase activity
GO:0071949 FAD binding
Biological Process
GO:0006537 glutamate biosynthetic process
GO:0006560 proline metabolic process
GO:0006562 proline catabolic process
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010133 proline catabolic process to glutamate
GO:0019470 4-hydroxyproline catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003526
View Gene Order
ENSBTAG00000047676
Not yet available
Pathways
NETPATH
REACTOME
REACT_1002
Proline catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517352
RefSeq NM_001195226 NM_016335
HUGO
OMIM
CCDS CCDS13754 CCDS56223
HPRD 08433
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca