InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HMOX1

Summary

InnateDB Gene

IDBG-637915.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMOX1

Gene Name

Heme oxygenase 1

Synonyms

HO-1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015582

Encoded Proteins

IDBP-689947

Heme oxygenase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21307647

[Homo sapiens] HMOX1, a downstream signalling molecule in the TLR4 pathway, is necessary for LPS-induced autophagy signalling in macrophages.

PMID 21307647

[Mus musculus] Hmox1, a downstream signalling molecule in the Tlr4 pathway, is necessary for LPS-induced autophagy signalling in macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100292:
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:73980776-73987841

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020701

ENSBTAP00000020701

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004392	heme oxygenase (decyclizing) activity
GO:0004871	signal transducer activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0002246	wound healing involved in inflammatory response
GO:0006788	heme oxidation
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0034101	erythrocyte homeostasis
GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
GO:0035094	response to nicotine
GO:0042167	heme catabolic process
GO:0042168	heme metabolic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051260	protein homooligomerization
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0071243	cellular response to arsenic-containing substance
GO:0071276	cellular response to cadmium ion
GO:0071456	cellular response to hypoxia
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle