InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HMOX1

Summary

InnateDB Protein

IDBP-689947.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMOX1

Protein Name

Heme oxygenase 1

Synonyms

HO-1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020701

InnateDB Gene

IDBG-637915 (HMOX1)

Protein Structure

UniProt Annotation

Function

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Microsome {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004392	heme oxygenase (decyclizing) activity
GO:0004871	signal transducer activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0002246	wound healing involved in inflammatory response
GO:0006788	heme oxidation
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0034101	erythrocyte homeostasis
GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
GO:0035094	response to nicotine
GO:0042167	heme catabolic process
GO:0042168	heme metabolic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051260	protein homooligomerization
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0071243	cellular response to arsenic-containing substance
GO:0071276	cellular response to cadmium ion
GO:0071456	cellular response to hypoxia
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR002051 Haem oxygenase
IPR016053 Haem oxygenase-like
IPR016084 Haem oxygenase-like, multi-helical

PFAM

PF01126

PRINTS

PR00088

PIRSF

PIRSF000343

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9F2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

513221

UniGene

Bt.4001

RefSeq

NP_001014912

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102105 BT020968

GenPept

AAI02106 AAX08985