InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.65955

Summary

InnateDB Gene

IDBG-637933.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.65955

Gene Name

uromodulin precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006264

Encoded Proteins

IDBP-689974

uromodulin precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169344:
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:18124563-18143260

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000046009

ENSBTAP00000043345

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019864	IgG binding

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007588	excretion
GO:0048878	chemical homeostasis
GO:0072218	metanephric ascending thin limb development
GO:0072221	metanephric distal convoluted tubule development
GO:0072233	metanephric thick ascending limb development
GO:1990266	neutrophil migration
GO:2000021	regulation of ion homeostasis

Cellular Component

GO:0000922	spindle pole
GO:0005576	extracellular region
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome
GO:0072372	primary cilium

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000169344

View Gene Order

ENSMUSG00000030963

View Gene Order

Cross-References

SwissProt

TrEMBL

F1MCQ0

UniProt Splice Variant

Entrez Gene

281567

UniGene

Bt.65955

RefSeq

NM_174213

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02057632 DAAA02057633

GenPept

RNA Seq Atlas

281567