Version 5.4
Mus musculus Gene: Umod
Summary
InnateDB Gene IDBG-207931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Umod
Gene Name uromodulin
Synonyms THP; Urehd1; urehr4
Species Mus musculus
Ensembl Gene ENSMUSG00000030963
Encoded Proteins
IDBP-207933
uromodulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:119462866-119479255
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000033263 ENSMUSP00000033263
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019864 IgG binding
Biological Process
GO:0007157 heterophilic cell-cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007588 excretion
GO:0010033 response to organic substance
GO:0048878 chemical homeostasis
GO:0072218 metanephric ascending thin limb development
GO:0072221 metanephric distal convoluted tubule development
GO:0072233 metanephric thick ascending limb development
GO:1990266 neutrophil migration
GO:2000021 regulation of ion homeostasis
Cellular Component
GO:0000922 spindle pole
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
GO:0031410 cytoplasmic vesicle
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0060170 ciliary membrane
GO:0070062 extracellular vesicular exosome
GO:0072372 primary cilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169344
View Gene Order
ENSBTAG00000006264
Not yet available
Cross-References
SwissProt Q91X17
TrEMBL Q8CJA0
UniProt Splice Variant
Entrez Gene 22242
UniGene Mm.10826
RefSeq NM_001278605 NM_009470
OMIM
CCDS CCDS21780
HPRD
IMGT
MGI ID MGI:102674
MGI Symbol Umod
EMBL AF420599 AK085460 AK144065 AK164688 AK165507 BC012973 L33406
GenPept AAA73896 AAH12973 AAN32714 BAC39452 BAE25681 BAE37877 BAE38225
RNA Seq Atlas 22242

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca