Version 5.4
Bos taurus Gene: RBFOX2
Summary
InnateDB Gene IDBG-637948.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBFOX2
Gene Name RNA binding protein fox-1 homolog 2
Synonyms RBM9
Species Bos taurus
Ensembl Gene ENSBTAG00000020125
Encoded Proteins
IDBP-689994
RNA binding protein, fox-1 homolog (C. elegans) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100320:
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:74257475-74473002
Strand Reverse strand
Band
Transcripts
ENSBTAT00000026808 ENSBTAP00000026808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010724 regulation of definitive erythrocyte differentiation
GO:0021942 radial glia guided migration of Purkinje cell
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0043484 regulation of RNA splicing
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048813 dendrite morphogenesis
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100320
View Gene Order
ENSMUSG00000033565
View Gene Order
Cross-References
SwissProt
TrEMBL F1N2A9
UniProt Splice Variant
Entrez Gene 514951
UniGene Bt.3013
RefSeq NM_001205372 XM_005206787 XM_005206788 XM_005206791
HUGO HGNC:9906
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02013800
GenPept
RNA Seq Atlas 514951

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca