InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rbfox2

Summary

InnateDB Gene

IDBG-157578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbfox2

Gene Name

RNA binding protein, fox-1 homolog (C. elegans) 2

Synonyms

Fbm2; Fxh; Hrnbp2; Rbm9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033565

Encoded Proteins

IDBP-157580

RNA binding protein, fox-1 homolog (C. elegans) 2

IDBP-626852

RNA binding protein, fox-1 homolog (C. elegans) 2

IDBP-626849

RNA binding protein, fox-1 homolog (C. elegans) 2

IDBP-626851

RNA binding protein, fox-1 homolog (C. elegans) 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100320:
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:77078990-77307053

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048145	ENSMUSP00000048056
ENSMUST00000111581	ENSMUSP00000129372
ENSMUST00000171751	ENSMUSP00000130739
ENSMUST00000166610	ENSMUSP00000130673

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003714	transcription corepressor activity
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010724	regulation of definitive erythrocyte differentiation
GO:0021942	radial glia guided migration of Purkinje cell
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0043484	regulation of RNA splicing
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048813	dendrite morphogenesis
GO:0050885	neuromuscular process controlling balance

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000100320

View Gene Order

ENSBTAG00000020125

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.202774 Mm.397745 Mm.472147

RefSeq

NM_001110827 NM_001110828 NM_001110829 NM_001110830 NM_001286418 NM_053104 NM_175387 XM_006521574 XM_006521576 XM_006521577 XM_006521580 XM_006521591 XM_006521592 XM_006521593 XM_006521596 XM_006521597 XM_006521598 XM_006521599

OMIM

CCDS

CCDS27598 CCDS49657 CCDS49658 CCDS49659

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas