Version 5.4
Bos taurus Gene: BT.69126
Summary
InnateDB Gene IDBG-637988.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.69126
Gene Name prostaglandin reductase 1
Synonyms LTB4DH
Species Bos taurus
Ensembl Gene ENSBTAG00000011027
Encoded Proteins
IDBP-690026
prostaglandin reductase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106853:
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:102666740-102697281
Strand Reverse strand
Band
Transcripts
ENSBTAT00000014649 ENSBTAP00000014649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0032440 2-alkenal reductase [NAD(P)] activity
GO:0047522 15-oxoprostaglandin 13-oxidase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000106853
View Gene Order
ENSMUSG00000028378
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150420
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
REACT_150149
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_150320
Synthesis of Lipoxins (LX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_196544
Synthesis of Lipoxins (LX) pathway
REACT_188625
Arachidonic acid metabolism pathway
REACT_215561
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
KEGG
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1N2W0
UniProt Splice Variant
Entrez Gene 513177
UniGene Bt.51592 Bt.69126
RefSeq NM_001035281
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02024521 DAAA02024522
GenPept
RNA Seq Atlas 513177

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca