InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTGR1

Summary

InnateDB Gene

IDBG-80921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGR1

Gene Name

prostaglandin reductase 1

Synonyms

LTB4DH; PGR1; ZADH3

Species

Homo sapiens

Ensembl Gene

ENSG00000106853

Encoded Proteins

IDBP-80925

prostaglandin reductase 1

IDBP-80931

prostaglandin reductase 1

IDBP-295377

prostaglandin reductase 1

IDBP-377834

prostaglandin reductase 1

IDBP-591254

prostaglandin reductase 1

IDBP-592166

prostaglandin reductase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:111549722-111599855

Strand

Reverse strand

Band

q31.3

Transcripts

ENST00000309195	ENSP00000311572
ENST00000374324	ENSP00000363444
ENST00000374313
ENST00000374308
ENST00000407693	ENSP00000385763
ENST00000422125	ENSP00000395965
ENST00000466771	ENSP00000435665
ENST00000485319
ENST00000538962	ENSP00000440281

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0032440	2-alkenal reductase [NAD(P)] activity
GO:0036132	13-prostaglandin reductase activity
GO:0047522	15-oxoprostaglandin 13-oxidase activity

Biological Process

GO:0006691	leukotriene metabolic process
GO:0009636	response to toxic substance
GO:0019369	arachidonic acid metabolic process
GO:0019371	cyclooxygenase pathway
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:2001300	lipoxin metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028378

View Gene Order

ENSBTAG00000011027

Not yet available

Pathways

NETPATH

REACTOME

REACT_150420

Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway

REACT_150149

Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway

REACT_150320

Synthesis of Lipoxins (LX) pathway

REACT_147851

Arachidonic acid metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

INOH

INOH website

Glycine Serine metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.584864 Hs.740215

RefSeq

NM_001146108 NM_001146109 NM_012212

HUGO

OMIM

CCDS

CCDS55331 CCDS6779

HPRD

03173

IMGT

EMBL

GenPept

RNA Seq Atlas