InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PLOD2

Summary

InnateDB Gene

IDBG-638010.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLOD2

Gene Name

procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007331

Encoded Proteins

IDBP-690056

procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152952:
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:123322467-123444003

Strand

Forward strand

Band

Transcripts

ENSBTAT00000031949

ENSBTAP00000031895

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008475	procollagen-lysine 5-dioxygenase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding