Version 5.4
Bos taurus Gene: PDIA6
Summary
InnateDB Gene IDBG-638031.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDIA6
Gene Name protein disulfide-isomerase A6 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001928
Encoded Proteins
IDBP-690214
PDIA6 proteinUncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143870:
Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:86834898-86857648
Strand Forward strand
Band
Transcripts
ENSBTAT00000002508 ENSBTAP00000002508
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
Biological Process
GO:0006457 protein folding
GO:0008152 metabolic process
GO:0034976 response to endoplasmic reticulum stress
GO:0043277 apoptotic cell clearance
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143870
View Gene Order
ENSMUSG00000020571
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A6QNL5 Q0V8C4
UniProt Splice Variant
Entrez Gene 613927
UniGene Bt.62707 Bt.6460
RefSeq NM_001206345
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148886 BT026295 DAAA02031921
GenPept AAI48887 ABG81451
RNA Seq Atlas 613927

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca