InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.24520

Summary

InnateDB Gene

IDBG-638042.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.24520

Gene Name

B-cell linker protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021358

Encoded Proteins

IDBP-690085

B-cell linker protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095585:
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:17380665-17466937

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000056369

ENSBTAP00000051686

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.