Version 5.4
Mus musculus Gene: Blnk
Summary
InnateDB Gene IDBG-165316.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Blnk
Gene Name B cell linker
Synonyms BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65
Species Mus musculus
Ensembl Gene ENSMUSG00000061132
Encoded Proteins
IDBP-165318
B-cell linker
IDBP-401075
B-cell linker
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095585:
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40928927-40994535
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000054769 ENSMUSP00000057844
ENSMUST00000117695 ENSMUSP00000112473
ENSMUST00000134568
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0035556 intracellular signal transduction
GO:0042113 B cell activation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000095585
View Gene Order
ENSBTAG00000021358
Not yet available
Pathways
NETPATH
REACTOME
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188194
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_261687
Signaling by Interleukins pathway
REACT_229531
Adaptive Immune System pathway
REACT_225836
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_198634
Regulation of signaling by CBL pathway
KEGG
mmu04662
B cell receptor signaling pathway pathway
mmu05340
Primary immunodeficiency pathway
mmu04380
Osteoclast differentiation pathway
INOH
INOH website
B cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_23787
Regulation of signaling by CBL pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
KEGG
hsa04662
B cell receptor signaling pathway pathway
hsa05340
Primary immunodeficiency pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
B cell receptor signaling pathway
PID NCI
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt Q9QUN3
TrEMBL
UniProt Splice Variant
Entrez Gene 17060
UniGene Mm.415818 Mm.9749
RefSeq NM_008528
OMIM
CCDS CCDS37983
HPRD
IMGT
MGI ID MGI:96878
MGI Symbol Blnk
EMBL AB015290 AF068182 AJ298054 BC059785 Y17159
GenPept AAC40206 AAH59785 BAA34944 CAA76666 CAC18565
RNA Seq Atlas 17060

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca