InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: OTC

Summary

InnateDB Gene

IDBG-638092.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OTC

Gene Name

ornithine carbamoyltransferase, mitochondrial precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001488

Encoded Proteins

IDBP-690137

ornithine carbamoyltransferase, mitochondrial precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000036473:
This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:110318974-110395520

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001947

ENSBTAP00000001947

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004585	ornithine carbamoyltransferase activity
GO:0016597	amino acid binding
GO:0016740	transferase activity
GO:0016743	carboxyl- or carbamoyltransferase activity

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0006593	ornithine catabolic process
GO:0019240	citrulline biosynthetic process
GO:0097272	ammonia homeostasis