InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: COMT

Summary

InnateDB Gene

IDBG-638156.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COMT

Gene Name

Catechol O-methyltransferase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019516

Encoded Proteins

IDBP-690206

Catechol O-methyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000093010:
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:74927012-74927547

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025997

ENSBTAP00000025997

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0008168	methyltransferase activity
GO:0008171	O-methyltransferase activity
GO:0016206	catechol O-methyltransferase activity
GO:0016740	transferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006584	catecholamine metabolic process
GO:0009712	catechol-containing compound metabolic process
GO:0016036	cellular response to phosphate starvation
GO:0032259	methylation
GO:0042135	neurotransmitter catabolic process
GO:0042417	dopamine metabolic process
GO:0042420	dopamine catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome