InnateDB Protein
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IDBP-690206.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COMT
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Protein Name
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Catechol O-methyltransferase
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000025997
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InnateDB Gene
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IDBG-638156 (COMT)
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Protein Structure
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Function |
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity). {ECO:0000250}.
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Subcellular Localization |
Isoform 2: Cytoplasm {ECO:0000250}.Isoform 1: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002935
O-methyltransferase, family 3
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
PF01596
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A7MBI7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
F1MMK0
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UniProt Splice Variant |
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Entrez Gene |
618278
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UniGene |
Bt.33191
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RefSeq |
NP_001095787
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC151585
DAAA02045779
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GenPept |
AAI51586
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